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KMID : 1134820120410050630
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 5 p.630 ~ p.637
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Effects of Puffed and Fermented Red Ginseng on Blood Glucose-related Biomarkers in Streptozotocin-Induced Diabetic Rats
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Park Ju-Hun
Seong Ki-Seung
Kim Sung-Soo
Sim Gun-Sub
Han Chan-Kyu
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Abstract
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This study was performed to investigate the effects of puffed and fermented red ginseng on blood glucose-related biomarkers in streptozotocin-induced diabetic rats. Male Sprague-Dawley diabetic rats were orally injected with 0.85% NaCL as a diabetic control (DC), 300 mg/kg general red ginseng (RG), 300 mg/kg puffing red ginseng fermented by mixed strain culture of Bifidobacterium breve and Lactobacillus delbrueckii (BL), and 300 mg/kg puffing red ginseng fermented by Enterococcus faecalis (EF) for 5 weeks. The blood glucose level of group BL was significantly lower maintained than in groups DC and RG for the experimental period (p<0.05). It was also significantly lower than in groups DC, RG, and EF at the 5th week (p<0.05). In the oral glucose tolerance test, the blood glucose of group BL was maintained the lowest level (p<0.05), and the area under the blood glucose curve (AUC) was also significantly lower in group BL than in group DC (p<0.05). The fasting blood glucose and insulin levels after the experiment were significantly low in group BL (p<0.05), and the HOMA-IR was more significantly low in groups BL and EF than in group DC (p<0.05). Also, the HbA1c content of group BL was significantly low than in groups DC and RG (p<0.05). The serum TC level was significantly decreased in groups RG, BL, and EF than in group DC (p<0.05), and the LDL-C content was significantly low in group BL than in group DC (p<0.05). From the findings, it was shown that the puffed and fermented red ginseng made using a mixed strain culture of B. breve and L. delbrueckii could improve blood glucose-related biomarkers.
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KEYWORD
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puffed and fermented red ginseng, Bifidobacterium breve, Lactobacillus delbrueckii, blood glucose, diabetic rats
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